An assessment of the safety and efficacy of a software-based OrthoK fitting algorithm for myopia correction

A custom-tailored approach for OrthoK fitting for better efficacy

OrthoK Treatment Based on Advanced Corneal Profiling


The aim of this study is to find out more about how these overnight contact lenses that are designed by a fitting software fit on your eyes, comparing to a conventional fitting methods that only rely a few factors. 

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This study aims to compare the accuracy, efficiency, and clinical outcomes of a software-guided fitting system versus the traditional empirical method in prescribing Euclid OrthoK lenses for myopia management. Both the design and the material for lenses used in the study are FDA approved.

The software-based method uses advanced algorithms and corneal topography data to automatically recommend lens parameters, while the empirical method relies on the practitioner’s interpretation of data and historical fitting nomograms to determine lens design.

No. All lenses used are Euclid OrthoK lenses, FDA-approved and clinically validated. The difference lies only in how the lens parameters are determined—not the lens material or quality.

The study may help improve the precision and efficiency of OrthoK lens fitting, potentially reducing chair time and improving outcomes for future patients. You’ll also receive comprehensive follow-up care as part of the study.

Yes. You will receive $30/follow-up visit. If you prefer this method of vision correction, and you are determined to be a good candidate to continue to wear these lenses, you may also receive a pair of lenses at no charge after study completion. Details will be provided in the consent form.

After the study concludes, Dr. Liu will review your clinical outcomes and discuss whether to continue with your current OrthoK lenses or modify your treatment. You’ll also have the option to transition into standard clinical care with continued monitoring and support.

We are looking for subjects between 7–40 years old who has no previous history of OrthoK treatment, with myopia within -0.50D to -5.00D and astigmatism of no more than 2.00D. A brief screening exam and review of your eye health history will be conducted to confirm eligibility. The research team will explain everything clearly before enrollment.

Typical Clinic Flow for OrthoK treatment in a clinical study setting

  • Refraction & ocular health assessment
  • Establish study eligibility & complete study questionnaire
  • Answer questions related to the study
  • Order study lenses & schedule follow-up visits
  • Assess the fitting of lenses
  • Training on lens application & removal, and daily cleaning routine
  • Answer your questions
  • Schedule for follow up visits 
  • Check vision
  • Evaluate fitting of lenses
  • Assess ocular health
  • Adjust or finalize lens design & parameters
  • Review lens handling procedure
  • Schedule for follow-up visits (1w, 2w, and 4w)
  • Check vision
  • Assess ocular health
  • Evaluate lens fitting
  • Inspect lens condition & review lens wear an care routine
  • Adjust design or parameters if necessary
  • Prepare for study exit